Peran Curcumin dalam Non-alcoholic Fatty Liver Disease (NAFLD)

Oleh :

dr. Hendra Gunawan SpPD

Peran curcumin pada non-alcoholic fatty liver disease atau fatty liver sudah pernah diteliti sebelumnya. Dalam studi beberapa tahun terakhir, curcumin diteliti memiliki efek antioksidan dan antiinflamasi. Berdasarkan dari hal ini, muncul dugaan apakah curcumin juga bermanfaat pada penanganan NAFLD.

Kunyit dan ekstraknya, curcumin merupakan salah satu obat tradisional yang memiliki potensi protektif terhadap organ hati. Studi pada hewan coba melaporkan bahwa curcumin dapat memperbaiki tingkat keparahan dari steatohepatitis dengan menghambat Nuclear Factor-êB (NF-êB). [1,2]

Non-alcoholic fatty liver disease (NAFLD) atau perlemakan hati merupakan salah satu penyakit hati yang paling sering dijumpai. Penyakit ini memiliki prevalensi hingga 25% di seluruh dunia.[3] Gejala yang sering dijumpai adalah asimtomatik hingga gejala ringan seperti nyeri abdomen kanan atas maupun kelelahan.[4]

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Referensi

1. Alm-Eldeen AA, Mona MH, Shati AA, El-Mekkawy HI. Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats. Toxicol Ind Health. 2015;31(12):1269-80.
2. Leclercq IA, Farrell GC, Sempoux C, dela Peña A, Horsmans Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol. 2004;41(6):926-34.
3. Cotter TG, Rinella M. Nonalcoholic Fatty Liver Disease 2020: The State of the Disease. Gastroenterology. 2020;158(7):1851-64.
4. Mayo Clinic. Nonalcoholic fatty liver disease Arizona: Mayo Clinic; 2020 [cited 2020 November 3]. Available from: https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/symptoms-causes/syc-20354567.
5. Shi T, Wu L, Ma W, Ju L, Bai M, Chen X, et al. Nonalcoholic Fatty Liver Disease: Pathogenesis and Treatment in Traditional Chinese Medicine and Western Medicine. Evidence-Based Complementary and Alternative Medicine. 2020;2020:8749564.
6. Lee DE, Lee SJ, Kim SJ, Lee HS, Kwon OS. Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O-GlcNAcylation. Nutrients. 2019;11(11).
7. Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, et al. Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo- controlled Trial. Phytotherapy Research. 2016;30(9):1540-8.
8. Panahi Y, Kianpour P, Mohtashami R, Soflaei S, Sahebkar A. Efficacy of phospholipidated curcumin in nonalcoholic fatty liver disease: a clinical study. Journal of Asian Natural Products Research. 2018;2018(2):1-8.
9. Mansour-Ghanaei F, Pourmasoumi M, Hadi A, Joukar F. Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials. Integr Med Res. 2019;8(1):57-61.
10. Saadati S, Hatami B, Yari Z, Shahrbaf M, Eghtesad S, Mansour A, et al. The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. European Journal of Clinical Nutrition. 2019;441-449.
11. Luber RP, Rentsch C, Lontos S, Pope JD, Aung AK, Schneider HG, et al. Turmeric Induced Liver Injury: A Report of Two Cases. Case Reports in Hepatology. 2019;2019:6741213.
12. White MC, Lee J-Y. The impact of turmeric or its curcumin extract on nonalcoholic fatty liver disease: a systematic review of clinical trials. Pharmacy Practice. 2019;17(1):11-9.
13. Marinda FD. Hepatoprotective Effect Of Curcumin in Chronic Hepatitis. Medical Journal of Lampung University. 2014;3(7):52-6.