Mengembalikan Integritas Epidermal: Peran Multi-Type Ceramide Untuk Kondisi Kulit Wajah

Oleh :

dr. Nurul Falah

Multi-type ceramide membantu mengembalikan integritas epidermal untuk kondisi wajah dengan kerusakan skin barrier. Studi dermatologi terkini menunjukkan bahwa kerusakan skin barrier yang mengakibatkan kondisi kulit sensitif, kulit berjerawat atau acne prone, dan pasca penggunaan bahan aktif semakin umum dijumpai akibat peningkatan kasus yang terjadi secara signifikan.[1]

Faktor risiko paparan lingkungan seperti polusi udara, radiasi sinar UV, dan cuaca ekstrem dapat mengganggu integritas stratum korneum. Penggunaan produk perawatan kulit yang tidak tepat, eksfoliasi berlebihan, atau penggunaan bahan kimia keras seperti alkohol dan pewangi juga terbukti mengikis lapisan lipid alami kulit dan merusak keseimbangan mikrobioma, sehingga memicu inflamasi dan sensitivitas.[2]

Dalam praktik dermatologi modern, menjaga integritas epidermal telah diakui sebagai prinsip fundamental dalam menjaga ketahanan skin barrier serta mengatasi permasalahan pada kulit terutama kulit wajah, sehingga penggunaan multi-type ceramide semakin disarankan.[1,3]

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Rajkumar J, Chandan N, Lio P, Shi V. The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair. Skin Pharmacol Physiol. 2023;36(4):174-185.
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3. Akiyama F, Takahashi N, Ueda Y, Tada S, Takeuchi N, Ohno Y, Kihara A. Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals. Int J Mol Sci. 2024 Jul 29;25(15):8291
4. Schild J, Kalvodová A, Zbytovská J, Farwick M, Pyko C. The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications. Int J Cosmet Sci. 2024 Aug;46(4):526-543.
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9. Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol. 2008 Aug;47(8):812-9.
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12. Yang Q, Liu M, Li X, Zheng J. The benefit of a ceramide-linoleic acid-containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses. Dermatologic Therapy. 2019; 32:e13017. https://doi.org/10.1111/dth.13017
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14. Ko K, Cheon GY, Ha YJ, et al. Enhanced Skin-Protective Effects of a Novel Centella Asiatica Variety (BT-Care) Cultivated for 75 Days via Modulation of Antioxidant Defense, Collagen Synthesis, and Skin Barrier Function. J Microbiol Biotechnol. 2025 Jul 14;35:e2504036.
15. Burnett CL, Boyer IJ, Bergfeld WF, et al. Safety assessment of ceramides as used in cosmetics. Int J Toxicol. 2020 Nov/Dec;39(3_suppl):5S-25S. doi:10.1177/1091581820958692.