Peran Curcumin pada Penatalaksanaan Drug Induced Liver Injury

Oleh :

Sunita

Peran curcumin dalam penatalaksanaan drug induced liver injury (DILI) mulai banyak dipelajari. Curcumin diduga memiliki efek terhadap modulasi mediator inflamasi, stres oksidatif, dan senyawa antioksidan di dalam sel hepar, sehingga memungkinkan untuk menjadi terapi dalam perbaikan seluler pasca cedera hepatosit.

DILI adalah efek samping pengobatan obat-obat hepatotoksik misalnya beberapa obat tuberkulosis, yang telah banyak dilaporkan. Efek samping ini dapat menyebabkan turunnya kepatuhan pasien terhadap pengobatan, kegagalan pengobatan, resistensi obat, dan bahkan kematian.

Kejadian DILI akibat obat antituberkulosis telah dilaporkan pada penggunaan berbagai farmakoterapi tuberkulosis, termasuk rifampicin, isoniazid (INH), pyrazinamide, dan ethambutol.

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Referensi

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