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Pendahuluan Nefritis Lupus
Nefritis lupus (lupus nephritis/LN) adalah inflamasi ginjal yang disebabkan oleh lupus eritematosus sistemik (LES). Penyakit ini merupakan manifestasi LES yang paling sering ditemui, dimana sekitar 40% pasien LES mengalami nefritis lupus.[1,2]
Umumnya, nefritis lupus terjadi setelah 5 tahun diagnosis lupus eritematosus sistemik (LES) ditegakkan atau sebaliknya, LES terdiagnosis setelah lupus nefritis didiagnosis. Nefritis lupus merupakan hipersensitivitas tipe 3, yang disebabkan oleh deposit imun kompleks dalam glomerulus.[1,2]
Manifestasi klinis nefritis lupus sangat beragam, dari asimptomatik sampai memiliki gejala edema, poliuria, nokturia, dan hipertensi. Pada nefritis lupus yang aktif, umumnya memiliki hasil kreatinin yang meningkat, rendahnya komplemen C3 dan C4, serta terdeteksinya anti dsDNA.[1,2,13]
Referensi
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