Pedoman Klinis Tapering Off Penggunaan Kortikosteroid

Oleh :

dr. Immanuel Natanael Tarigan

Pedoman klinis tapering off penggunaan kortikosteroid merupakan cara menghentikan atau menurunkan dosis kortikosteroid secara bertahap. Pedoman ini terutama untuk kortikosteroid yang sering sekali digunakan dalam jangka panjang.

Kortikosteroid merupakan sintesis analog hormon steroid yang diproduksi alami oleh tubuh. Sama dengan hormon steroid, kortikosteroid juga memiliki komponen glukokortikoid dan mineralokortikoid. Sejak ditemukan pertama kali, kortikosteroid banyak digunakan sebagai imunosupresan dan antiinflamasi.[1]

Prinsip Penggunaan Kortikosteroid

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

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4. Mundell L, Lindemann R, Douglas J. Monitoring long-term oral corticosteroids. BMJ Open Qual 2017; 6: e000209.
5. Williams DM. Clinical Pharmacology of Corticosteroids. Respir Care 2018; 63: 655–670.
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7. Paragliola RM, Papi G, Pontecorvi A, et al. Treatment with synthetic glucocorticoids and the hypothalamus-pituitary-adrenal axis. Int J Mol Sci; 18. Epub ahead of print 2017. DOI: 10.3390/ijms18102201.
8. Bhutta BS, Dominique E, Huecker MR. Adrenal Insufficiency. [Updated 2021 Feb 7]. Treasure Island (FL): StatPearls Publishing, https://www.ncbi.nlm.nih.gov/books/NBK441832/ (2021, accessed 10 March 2021).
9. Oprea A, Bonnet NCG, Pollé O, Lysy PA. Novel insights into glucocorticoid replacement therapy for pediatric and adult adrenal insufficiency. Ther Adv Endocrinol Metab. 2019;10:2042018818821294. Published 2019 Feb 2. doi:10.1177/2042018818821294
10. Caplan A, Fett N, Rosenbach M, et al. Prevention and management of glucocorticoid-induced side effects : A comprehensive review Gastrointestinal and endocrinologic side effects. J Am Dermatology 2017; 76: 11–16.
11. Upton J. Steroid tapering guidance, https://www.clatterbridgecc.nhs.uk/application/files/1314/9086/9715/Steroid_Tapering_and_supportive_treatment_Guidance_V1.0.pdf (2017).
12. Dasgupta B, Borg FA, Hassan N, et al. BSR and BHPR guidelines for the management of polymyalgia rheumatica. Rheumatology 2010; 49: 186–190.
13. Farinde A. Corticosteroid Dose Equivalents. Medscape. 2019. https://emedicine.medscape.com/article/2172042-overview

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