Obat Antiinflamasi Nonsteroid (OAINS) Topikal Untuk Nyeri Akut Muskuloskeletal

Oleh :

dr.Putra Rizki Sp.KO

Obat antiinflamasi nonsteroid (OAINS) topikal, seperti diklofenak dan ketoprofen, merupakan salah satu pilihan dalam tata laksana nyeri akut muskuloskeletal. Pemberian secara topikal dapat menghindari risiko efek samping dari pemberian OAINS sistemik, misalnya perdarahan saluran cerna, gangguan ginjal, ataupun risiko kardiovaskular.[1]

Peran Obat Antiinflamasi Nonsteroid Topikal dalam Manajemen Nyeri Akut Muskuloskeletal

Nyeri akut muskuloskeletal dapat timbul akibat sprain, strain, dislokasi, ataupun trauma tumpul. Nyeri akut muskuloskeletal paling sering terjadi pada usia produktif dan sering berhubungan dengan kegiatan olahraga.[2]

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Referensi

1. Machado GC, Abdel-Shaheed C, Underwood M, Day R O. Non-steroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain. BMJ 2021; 372 :n104 doi:10.1136/bmj.n104
2. Hsu JR, Mir H, Wally MK, Seymour RB. Clinical practice guidelines for pain management in acute musculoskeletal injury. J Orthop Trauma. 2019;33(5):e158–82.
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6. Canadian Agency for Drugs and Technologies in Health. Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness. Ottawa (ON); 2017. https://www.ncbi.nlm.nih.gov/books/NBK442145/
7. Zeng C, Wei J, Persson WM, et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Brit J Sports Med, 2018. 0:1-11. doi:10.1136/bjsports-2017-098043
8. Derry S, Moore RA, Gaskell H, McIntyre M, Wiffen PJ. Topical NSAIDs for acute musculoskeletal pain in adults. Cochrane Database Syst Rev. 2015;6:CD007402.
9. Derry S, Conaghan P, Da Silva JAP, Wiffen PJ, Moore RA. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: CD007400. DOI: 10.1002/14651858.CD007400.pub3.
10. Klinge SA, Sawyer GA. Effectiveness and safety of topical versus oral nonsteroidal anti-inflammatory drugs: A comprehensive review. Phys Sportsmed. 2015;41(2):64–74.

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