Fakta Terkini Penggunaan Isotretinoin yang Diduga Menyebabkan Inflammatory Bowel Disease dan Depresi

Oleh :

Graciella N T Wahjoepramono

Isotretinoin, modalitas pilihan untuk acne sedang-berat, dilaporkan menyebabkan efek samping berupa inflammatory bowel disease (IBD) dan depresi. Studi terkini justru mendapatkan hasil yang menentang hubungan antara isotretinoin dan kedua risiko efek samping tersebut.

Acne vulgaris merupakan kelainan klinis kulit yang sering terjadi dan diperkirakan mengenai 35% hingga 90% remaja [1], di mana 15–40% di antaranya diperkirakan mengalami acne sedang hingga berat. [2] Di antara modalitas terapi yang tersedia untuk acne, isotretinoin atau retinoid (vitamin A) sintetis adalah satu-satunya yang memiliki efektivitas tinggi terutama untuk terapi acne sedang hingga berat. Sebuah tinjauan pustaka dari 11 studi percobaan terkontrol menyimpulkan isotretinoin lebih superior dibandingkan plasebo maupun antibiotik sistemik. [3] Penggunaan isotretinoin terbukti dapat menurunkan produksi sebum, menghambat pembentukan komedo baru, sehingga menghambat pembentukan lesi acne inflamasi maupun noninflamasi. [4]

Sumber: AT Lima, jpogi, Wikimedia commons, 2010.

Risiko Efek Samping Isotretinoin

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Referensi

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