Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells

Machado RR, Glaser T, Araujo DB, et al. Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells. ACS Pharmacology & Translational Science. 2021 Sep 3;4(5):1514-27. PMID: 34651104.

Abstrak

Krisis kesehatan global telah terjadi akibat SARS-CoV-2 atau severe acute respiratory syndrome coronavirus 2. Peneliti mempelajari kemampuan larutan saline hipertonik menghambat replikasi SARS-CoV-2. Hasil menunjukkan bahwa NaCl 1,2% (saline hipertonik) bisa menghambat replikasi virus sebesar 90% dan NaCl 1,5% menghambat replikasi virus sebesar 100% pada sel ginjal primata Vero. Sementara itu, NaCl 1,1% menghambat replikasi virus sebesar 88% pada sel epitel paru Calu-3.