Injeksi Insulin Multipel VS Pompa Insulin untuk Diabetes Mellitus Tipe 1

Oleh :

dr.Shofa Nisrina Luthfiyani

Penggunaan injeksi insulin multipel atau multiple daily injection (MDI) merupakan terapi pemberian insulin standar yang diberikan pada pasien diabetes mellitus (DM) tipe 1. Akan tetapi, seiring dengan perkembangan teknologi, pemberian insulin dengan menggunakan pompa insulin atau continuous subcutaneous insulin therapy (CSII) semakin banyak digunakan.[1]

Diabetes Mellitus Tipe 1 dan Terapi Insulin

Diabetes mellitus (DM) tipe 1 merupakan salah satu penyakit kronik yang banyak ditemukan pada anak dan remaja. Di Indonesia sendiri telah ditemukan 852 anak dari tahun 1991 – 2012 yang menderita penyakit ini. Namun, angka ini diperkirakan lebih kecil dibandingkan angka sebenarnya karena masih banyak kasus yang tidak terdeteksi atau tidak dilaporkan.

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Janež A, Guja C, Mitrakou A, et al. Insulin Therapy in Adults with Type 1 Diabetes Mellitus: a Narrative Review. Diabetes Ther. 2020 Feb;11(2):387-409. doi: 10.1007/s13300-019-00743-7.
2. Pulungan A. Increasing incidence of DM type 1 in Indonesia. International Journal of Pediatric Endocrinology 2013. 2013(Suppl 1):O12
3. Blair J, McKay A, Ridyard C, Thornborough K, Bedson E, Peak M, et al. Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. Health Technol Assess. 2018;22(42)
4. Heller S. Relative eﬀectiveness of insulin pump treatment over multiple daily injections and structured education during ﬂexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ. 2017;356:j1285
5. Joshi M, Choudhary P. Multiple Daily Injections OR Insulin Pump Therapy: Choosing the Best Option for Your Patient—An Evidence-based Approach. Curr Diab Rep. 2015:81-86
6. American Diabetes Association Professional Practice Committee for Diabetes*; 7. Diabetes Technology: Standards of Care in Diabetes—2026. Diabetes Care 1 January 2026; 49 (Supplement_1): S150–S165. https://doi.org/10.2337/dc26-S007
7. Misso ML, Egberts KJ, Page M, O’Connor D, Shaw J. Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. Cochrane Database Syst Rev. 2010;(1):CD005103
8. Karges B, Schwandt A, Heidtmann B, Kordonouri O, Binder E, Schierloh U, et al. Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes. JAMA. 2017;318(14):1358-1366
9. REPOSE Study Group. Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ. 2017 Mar 30;356:j1285. doi: 10.1136/bmj.j1285.
10. Haughton S, Riley D, Berry S, et al. The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: A real-world retrospective cohort study. Diabetes Obes Metab. 2025 Aug;27(8):4239-4247. doi: 10.1111/dom.16455.
11. Rys PM, Ludwig-Slomczynska AH, Cyganek K, Malecki MT. Continuous subcutaneous insulin infusion vs multiple daily injections in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials and observational studies. European Journal of Endocrinology. 2018;178:545-563
12. Jankovec Z, Hahn M, Grunder S, Lacigova S, Cechurova D, Krcma M, et al. Analysis of continuous patient data from the Czech National Register of patients with type 1 and type 2 diabetes using insulin pump therapy. Diabetes Research and Clinical Practice. 2010;87:219–223