Injeksi Insulin Multipel VS Pompa Insulin untuk Diabetes Mellitus Tipe 1

Oleh :

dr.Shofa Nisrina Luthfiyani

Penggunaan injeksi insulin multipel atau multiple daily injection (MDI) merupakan terapi pemberian insulin standar yang diberikan pada pasien diabetes mellitus (DM) tipe 1. Akan tetapi, seiring dengan perkembangan teknologi, pemberian insulin dengan menggunakan pompa insulin atau continuous subcutaneous insulin therapy (CSII) mulai banyak digunakan. [1]

Diabetes Mellitus Tipe 1 dan Terapi Insulin

Diabetes mellitus (DM) tipe 1 merupakan salah satu penyakit kronik yang banyak ditemukan pada anak dan remaja. Di Indonesia sendiri telah ditemukan 852 anak dari tahun 1991 – 2012 yang menderita penyakit ini. Namun, angka ini diperkirakan lebih kecil dibandingkan angka sebenarnya karena masih banyak kasus yang tidak terdeteksi atau tidak dilaporkan. [2]

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Joshi M, Choudhary P. Multiple Daily Injections OR Insulin Pump Therapy: Choosing the Best Option for Your Patient—An Evidence-based Approach. Curr Diab Rep. 2015:81-86
2. Pulungan A. Increasing incidence of DM type 1 in Indonesia. International Journal of Pediatric Endocrinology 2013. 2013(Suppl 1):O12
3. Blair J, McKay A, Ridyard C, Thornborough K, Bedson E, Peak M, et al. Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. Health Technol Assess. 2018;22(42)
4. Heller S. Relative eﬀectiveness of insulin pump treatment over multiple daily injections and structured education during ﬂexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ. 2017;356:j1285
5. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, EURODIAB study group. Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet. 2009;373:2027–33
6. Misso ML, Egberts KJ, Page M, O’Connor D, Shaw J. Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. Cochrane Database Syst Rev. 2010;(1):CD005103
7. Karges B, Schwandt A, Heidtmann B, Kordonouri O, Binder E, Schierloh U, et al. Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes. JAMA. 2017;318(14):1358-1366
8. Xu G, Liu B, Sun Y, Du Y, Snetselaar L G, Hu F B et al. Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study BMJ 2018; 362 :k1497
9. National Institute for Health and Care Excellence (NICE). Continuous subcutaneous insulin infusion for the treatment of diabetes mellitus. NICE technology appraisal guidance 151. 2008. Available from: https://www.nice.org.uk/guidance/ta151
10. Diabetes UK. The United Kingdom Insulin Pump Audit- Service Level Data Online Source. 2013. Available from: https://jdrf.org.uk/wp-content/uploads/2015/10/The_United_Kingdom_Insulin_Pump_Audit_May_2013.pdf
11. Pickup J. Insulin pumps. Int J Clin Pract Suppl. 2011;170:16-9
12. Colstrup M, Mathiesen ER, Damm P, Jensen DM & Ringholm L. Pregnancy in women with type 1 diabetes: have the goals of St. Vincent declaration been met concerning foetal and neonatal complications?. Journal of Maternal-Fetal and Neonatal Medicine. 2013; 26: 1682–1686
13. Pickup JC & Sutton AJ. Severe hypoglycaemia and glycaemic control in Type1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabetic Medicine. 2008;25:765–774
14. Rys PM, Ludwig-Slomczynska AH, Cyganek K, Malecki MT. Continuous subcutaneous insulin infusion vs multiple daily injections in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials and observational studies. European Journal of Endocrinology. 2018;178:545-563
15. Jankovec Z, Hahn M, Grunder S, Lacigova S, Cechurova D, Krcma M, et al. Analysis of continuous patient data from the Czech National Register of patients with type 1 and type 2 diabetes using insulin pump therapy. Diabetes Research and Clinical Practice. 2010;87:219–223