Komplikasi Pulmonal pada GERD

Oleh :

dr. Shofa Nisrina Luthfiyani

GERD (gastroesophageal reflux disease) diduga dapat menimbulkan komplikasi pulmonal, seperti asthma, batuk persisten kronis, bronkitis kronis, aspirasi pulmonal, abses paru, bronkiektasis, pneumonitis aspirasi, fibrosis pulmonal idiopatik, penyakit paru obstruksi kronis, dan sindrom obstructive sleep apnea.

GERD merupakan kondisi terjadinya refluks konten lambung ke esofagus. Kondisi ini dapat disebabkan oleh beberapa hal, seperti gangguan sfingter esofagus bagian bawah, kelainan anatomi, misalnya hiatus hernia, dismotilitas esofagus, dan keterlambatan pengosongan lambung.[1,2]

Pengaruh GERD pada Sistem Pernapasan

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Gaude GS. Pulmonary manifestations of gastroesophageal reflux disease. Annals of Thoracic Medicine. 2009;4(3)
2. Griffiths TL, Nassar M, Soubani AO. Pulmonary manifestations of gastroesophageal reflux disease. Expert Rev Respir Med. 2020 Aug;14(8):767-775. doi: 10.1080/17476348.2020.1758068.
3. Garcia Rodriguez L, Ruigomez A, Martin-merino E, Johansson S, Wallander M. Relationship between gastroesophageal reﬂux disease and COPD in UK primary care. Chest. 2008;134(6):1223–1230
4. Qureshi F, Asad H, Patel PS, Ramprasad A, Singh SP, Suman S, Cheng AL, Salzman G. Gastroesophageal Reflux Disease-Associated Chronic Cough: A Population-Based Analysis of Patient Presentations in the United States. Cureus. 2021 Aug 27;13(8):e17512. doi: 10.7759/cureus.17512.
5. Lee AL, Goldstein RS. Gastroesophageal reflux in COPD: links and risks. International Journal of COPD. 2015;10:1935-1949
6. Baldomero AK, Wendt CH, Petersen A, Gaeckle NT, Han MK, Kunisaki KM; COPDGene Investigators. Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort. Respir Res. 2020 Aug 3;21(1):203. doi: 10.1186/s12931-020-01469-y.
7. Huang C, Liu Y, Shi G. A systematic review with meta-analysis of gastroesophageal reflux disease and exacerbations of chronic obstructive pulmonary disease. BMC Pulm Med. 2020 Jan 8;20(1):2. doi: 10.1186/s12890-019-1027-z.
8. Kikuchi S, Imai H, Tani Y, Tajiri T, Watanabe N. Proton pump inhibitors for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2020 Aug 25;8(8):CD013113. doi: 10.1002/14651858.CD013113.pub2.
9. Yu F, Huang Q, Ye Y, Zhang L. Effectiveness of Proton-Pump Inhibitors in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials. Front Med (Lausanne). 2022 Feb 16;9:841155. doi: 10.3389/fmed.2022.841155.
10. Hsu WT, Lai CC, Wang YH, Tseng PH, Wang K, Wang CY, et al. Risk of pneumonia in patients with gastroesophageal reflux disease: a population-based cohort study. PloS ONE. 2017;12(8)
11. Durazzo M, Lupi G, Cicerchia F, Ferro A, Barutta F, Beccuti G, Gruden G, Pellicano R. Extra-Esophageal Presentation of Gastroesophageal Reflux Disease: 2020 Update. J Clin Med. 2020 Aug 7;9(8):2559. doi: 10.3390/jcm9082559.
12. Ghisa M, Marinelli C, Savarino V, Savarino E. Idiopathic pulmonary fibrosis and GERD: links and risks. Ther Clin Risk Manag. 2019 Sep 5;15:1081-1093. doi: 10.2147/TCRM.S184291.
13. Costabel U, Behr J, Crestani B, et al. Anti-acid therapy in idiopathic pulmonary fibrosis: insights from the INPULSIS® trials. Respir Res. 2018;19(1):167. doi: 10.1186/s12931-018-0866-0

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