Izin menambahkan informasi.
Perlu ditanyakan juga indikasi dari penggunaan kombinasi ketiganya,  serta berapa lama pasien telah menggunakan sebelumnya. 
Ada baiknya penggunaan pun disesuaikan dengan kondisi si pasien.
Perlu diingat beberapa faskes dan peraturan pemerintahpun mengatur dokter apa yang dianggap boleh meresepkan dan jumlah peresepannya.
Selain itu perlu diperhatikan bahwa penggunaan benzodiazepin lebih dari 2 -3 minggu akan memicu adanya efek ketergantungan,  toleransi bahkan putus zat saat obat di stop.
Tappering off sendiri berguna untuk mencegah terjadinya kejang pada kasus delirium akibat sindroma putus zat.
Penting untuk menimbang besaran manfaat dan risiko yang timbul. Terutama risiko akibat salah peresepan.
Jangan lupa,  bahwa terdapat efek lain dari penggunaan lama benzodiazepin mulai dari penurunan fungsi kognitif (terutama daerah inhibisi)  bahkan agresivitas.
Semoga membantu

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ALO,  Dokter,  izin berdiskusi,  pemberian obat terutama golongan benzodiazepine sangat bergantung pada indikasi dan dosis yang diberikan terutama bila diberikan dalam bentuk kombinasi.
Pasien yang meminum obat alprazolam bersama obat dengan efek depresi saraf pusat lainnya seperti clobazam akan meningkatkan risiko timbulnya efek samping obat,  namun hal ini juga sangat bergantung dengan jumlah dosis yang diberikan.
Berikut terdapat tautan yang dapat menjadi referensi lebih lanjut.. https://www.alomedika.com/obat/antiepilepsi-antikonvulsi/benzodiazepin/alprazolam/efek-samping-dan-interaksi-obat

Sebetulnya pemberian obat diatas tergantung dengan diagnosis dan tingkat keparahan gangguan mental, terutama pengguna napza terkadang terpaksa menggunakan obat tersebut sebagai substitusi. Sekarang tinggal bagaimana melakukan taffering offnya, sehingga penggunaan nafza off bebas rebound effek. dan benzodiazepin juga bisa distop juga bebas rebound effek. Sekedar tambahan.