Peran Aspirin dalam Tata Laksana Aneurisma Intrakranial

Oleh :

dr. Ade Wijaya SpN

Aspirin, suatu agen antiplatelet dan antiinflamasi, akhir-akhir ini banyak diteliti karena dipercaya dapat menghambat proses inflamasi yang berperan dalam progresi aneurisma intrakranial. Studi epidemiologi memprediksi bahwa aneurisma intrakranial terdapat pada sekitar 3% populasi. Jika aneurisma intrakranial ini ruptur, maka angka morbiditas dan mortalitasnya sangat tinggi.[1-7]

Diperkirakan angka kematian dari ruptur aneurisma intrakranial mencapai 42%, di mana 12% terjadi sebelum penderita sempat mencari pertolongan ke rumah sakit dan 30% lainnya meninggal dalam 30 hari pertama pasca ruptur. Berbagai studi menunjukkan bahwa inflamasi memiliki peranan penting dalam progresi pemburukan struktural dinding aneurisma yang kemudian dapat menyebabkan ruptur dari aneurisma tersebut.[1-4]

Peran Inflamasi dalam Proses Pembentukan dan Ruptur Aneurisma Intrakranial

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

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