Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blocker on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial

PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group. The Journal of the American Medical Association. 2020;323(7):616-626. PMID: 31950977

Abstrak

Latar Belakang: Penghambat pompa proton dan antagonis reseptor histamin-2 sering diresepkan untuk profilaksis stress ulcer pada pasien di ruang perawatan intensif (ICU).  Efek komparatif kedua obat ini terhadap kematian belum diketahui.