Banyak pasien osteoarthritis lutut merupakan individu dengan obesitas, sehingga penurunan berat badan seharusnya menjadi terapi lini pertama pada populasi ini.
Proses patologi dari osteoarthritis lutut melibatkan hilangnya kartilago artikular, sklerosis tulang subkondral, hingga perkembangan osteofit. Meski begitu, belum terdapat terapi farmakologis definitif yang dapat menghentikan perkembangan proses patologis dari osteoarthritis lutut.[1-3]
Penggunaan farmakoterapi seperti analgesik dan antiinflamasi non-steroid (NSAID) hanya berperan sebagai terapi simptomatik, dan tidak dapat diberikan sebagai terapi jangka panjang karena berbagai pertimbangan, seperti adanya efek samping negatif pada sistem gastrointestinal, ginjal, dan kardiovaskular. Oleh sebab itu, pendekatan terapi non-farmakologis berperan penting dalam penanganan osteoarthritis lutut, termasuk penurunan berat badan pada pasien dengan overweight dan obesitas.[2,3]
(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)
Referensi
1. Aziz A M K. Management of Early Osteoarthritis. Intech Open. 2020;0:1-9 DOI: http://dx.doi.org/10.5772/intechopen.93582
2. Mazzei D.R, Whittaker J.L, et al. Do people with knee osteoarthritis use guideline-consistent treatments after an orthopaedic surgeon recommends nonsurgical care? A cross-sectional survey with long-term follow-up. Osteoarthritis and Cartilage Open. 2022;4(100256):1-8 DOI: https://doi.org/10.1016/j.ocarto.2022.100256
3. Inam S, Riaz B, Jamil H, et al. Do Patients With Osteoarthritis get Weight Loss Counseling?. Cureus. 2020;12(11):e11502. DOI: 10.7759/cureus.11502
4. Uivaraseanu B, Vesa C M, Tit D M, et al. Therapeutic approaches in the management of knee osteoarthritis. Experimental and Therapeutic Medicine. 2022;23(328):1-6 DOI:10.3892/etm.2022.11257
5. Kan HS, Chan PK, Yan CH, et al. Non-surgical treatment of knee osteoarthritis. Hong Kong Medical Journal. 2019;25(2):127-133 DOI: https://doi.org/10.12809/hkmj187600
6. Alhamo M A, Weheida S M, et al. Knee Osteoarthritis Evidence Based Guidelines Management: The Missing Truth. ASNJ. 2019;21(2):1-10
7. Amirkhizi F, Ghoreishy S M, et al. Higher dietary phytochemical index is associated with lower odds of knee osteoarthritis. Scientific Reports. 2022;12(9059):1-8 DOI: https://doi.org/10.1038/s41598-022-13019-1
8. Zeng J, Franklin D K, et al. The effects of dietary patterns and food groups on symptomatic osteoarthritis: A systematic review. Nutrition & Dietetics. 2023;80:21–43 DOI: 10.1111/1747-0080.12781
9. Sadeghi A, Zarrinjooiee G, et al. Effects of a Mediterranean Diet Compared with the Low-Fat Diet on Patients with Knee Osteoarthritis: A Randomized Feeding Trial. Hindawi International Journal of Clinical Practice. 2022;7275192:1-7 DOI: https://doi.org/10.1155/2022/7275192
10. Sikalidis A K, Kelleher A H, Kristo A S. Mediterranean Diet. Encyclopedia. 2021;1(2):371-387 DOI: https://doi.org/10.3390/encyclopedia1020031
11. Joseph G, McCulloch CE, et al. Effect of Weight Change On Knee and Hip Radiographic Measurements and Pain Over 4 Years: Data From The Osteoarthritis Initiative. Osteoarthritis and Cartilage. 2022;30:S7-S80
12. Landsmeer M.LA, Vos B.C, et al. Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women. Osteoarthritis and Cartilage. 2018;26:1666-1674 DOI: https://doi.org/10.1016/j.joca.2018.08.006
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