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Patofisiologi Infeksi Virus Zika
Patofisiologi infeksi virus Zika dimulai dari transmisi oleh vektor nyamuk Aedes atau jalur transmisi lainnya yang kemudian dilanjutkan dengan replikasi virus dalam sel host yang menyebabkan kerusakan terutama pada sistem saraf, visual, muskuloskeletal, dan kardiovaskular.
Virus Zika dapat menembus plasenta sehingga menginfeksi janin pada ibu yang terinfeksi dan menyebabkan sindrom Zika kongenital. Infeksi virus Zika juga dapat mencetuskan sindrom Guillain-Barre (SGB) pada pasien dewasa.[1,20,28]
Jalur Transmisi
Referensi
1. Wolford RW, Schaefer TJ. Zika Virus. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK430981/
2. Labeaud, AD. Zika virus infection: An overview. 2025. https://www.uptodate.com/contents/zika-virus-infection-an-overview
3. Navalkele BD, Levine M. Zika Virus. 2025. https://emedicine.medscape.com/article/2500035-overview
10. Cunha AJ, de Magalhães-Barbosa MC, Lima-Setta F, et al. Microcephaly Case Fatality Rate Associated with Zika Virus Infection in Brazil: Current Estimates. The Pediatric infectious disease journal, 2017. 36(5), 528–530. https://doi.org/10.1097/INF.0000000000001486
11. Masmejan, S., Musso, D., Vouga, M., et al. Zika Virus. Pathogens (Basel, Switzerland), 2020. 9(11), 898. https://doi.org/10.3390/pathogens9110898
12. Manangeeswaran, M., Kielczewski, J. L., Sen, H. N., et al. ZIKA virus infection causes persistent chorioretinal lesions. Emerging microbes & infections, 2018. 7(1), 96. https://doi.org/10.1038/s41426-018-0096-z
13. Hussain, A., Ali, F., Latiwesh, O. B., et al. A Comprehensive Review of the Manifestations and Pathogenesis of Zika Virus in Neonates and Adults. Cureus, 2018. 10(9), e3290. https://doi.org/10.7759/cureus.3290
14. Edupuganti, S., Natrajan, M. S., Rouphael, N., et al. Biphasic Zika Illness With Rash and Joint Pain. Open forum infectious diseases, 2017. 4(3), ofx133. https://doi.org/10.1093/ofid/ofx133
15. Wimalasiri-Yapa, B., Yapa, H. E., Huang, X., et al. Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis. Viruses, 2020. 12(10), 1137. https://doi.org/10.3390/v12101137
17. Vroon, P., Roosblad, J., Poese, F., et al. Severity of acute Zika virus infection: A prospective emergency room surveillance study during the 2015-2016 outbreak in Suriname. IDCases, 2017. 10, 117–121. https://doi.org/10.1016/j.idcr.2017.10.007
18. Agrawal, R., Oo, H. H., Balne, P. K., et al. Zika Virus and the Eye. Ocular immunology and inflammation, 2018. 26(5), 654–659. https://doi.org/10.1080/09273948.2017.1294184
20. Public Health England. Zika virus and Guillain Barre Syndrome. 2017. https://www.gov.uk/guidance/Zika-virus-and-guillain-barre-syndrome
22. Kazmi, S. S., Ali, W., Bibi, N., et al. A review on Zika virus outbreak, epidemiology, transmission and infection dynamics. Journal of biological research (Thessalonike, Greece), 2020. 27, 5. https://doi.org/10.1186/s40709-020-00115-4
25. Baz M, Boivin G. Antiviral Agents in Development for Zika Virus Infections. Pharmaceuticals (Basel, Switzerland), 2019. 12(3), 101. https://doi.org/10.3390/ph12030101
28. Leonhard, S. E., Bresani-Salvi, C. C., Lyra Batista, J. D., et al. Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype. PLoS neglected tropical diseases, 2020. 14(4), e0008264. https://doi.org/10.1371/journal.pntd.0008264
30. Wen, Z., Song, H., & Ming, G. L. How does Zika virus cause microcephaly?. Genes & development, 2017. 31(9), 849–861. https://doi.org/10.1101/gad.298216.117
33. Gorshkov, K., Shiryaev, S. A., Fertel, S., et al. Zika Virus: Origins, Pathological Action, and Treatment Strategies. Frontiers in microbiology, 2019. 9, 3252. https://doi.org/10.3389/fmicb.2018.03252
35. Noorbakhsh, F., Abdolmohammadi, K., Fatahi, Y., Dalili, H., Rasoolinejad, M., Rezaei, F., Salehi-Vaziri, M., Shafiei-Jandaghi, N. Z., Gooshki, E. S., Zaim, M., & Nicknam, M. H. Zika Virus Infection, Basic and Clinical Aspects: A Review Article. Iranian journal of public health, 2019. 48(1), 20–31.
36. N Costa, Maria Conceição et al. Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †.” Virusesvol. 2020. 12,11 1228. doi:10.3390/v12111228
37. Perkasa, A., Yudhaputri, F., Haryanto, S., Hayati, R. F., Ma'roef, C. N., Antonjaya, U., Yohan, B., Myint, K. S., Ledermann, J. P., Rosenberg, R., Powers, A. M., & Sasmono, R. T. Isolation of Zika Virus from Febrile Patient, Indonesia. Emerging infectious diseases, 2016. 22(5), 924–925. https://doi.org/10.3201/eid2205.151915
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