- Pendahuluan
- Farmakologi
- Formulasi
- Indikasi dan Dosis
- Efek Samping dan Interaksi Obat
- Penggunaan pada Kehamilan dan Ibu Menyusui
- Kontraindikasi dan Peringatan
- Pengawasan Klinis
Formulasi Losartan
Formulasi losartan yang ada di Indonesia adalah sediaan oral berbentuk tablet dan kaplet. Konsumsi losartan dapat dibarengi ataupun tanpa makanan.[13-16]
Bentuk Sediaan
Di Indonesia, losartan tersedia dalam bentuk tablet dan kaplet oral dengan kekuatan sediaan 25 mg, 50 mg, dan 100 mg.[16,28]
Referensi
1. Teixido-Tura G, Forteza A, Rodríguez-Palomares J, González Mirelis J, Gutiérrez L, Sánchez V, et al. Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome. J Am Coll Cardiol 2018;72:1613–8. https://doi.org/10.1016/j.jacc.2018.07.052.
2. van Driest SL, Sleeper LA, Gelb BD, Morris SA, Dietz HC, Forbus GA, et al. Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome. Journal of Pediatrics 2020;222:213-220.e5. https://doi.org/10.1016/j.jpeds.2020.03.064.
13. DrugBank Losartan. 2022. https://go.drugbank.com/drugs/DB00678.
14. MIMS. Losartan. 2022. https://www.mims.com/indonesia/drug/info/losartan
15. Zou J, Zhou X, Ma Y, Yu R. Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-β/Smad. Biomedicine and Pharmacotherapy 2022;149. https://doi.org/10.1016/j.biopha.2022.112931.
16. Kim DY, Choi MJ, Ko TK, Lee NH, Kim OH, Cheon HG. Angiotensin AT1 receptor antagonism by losartan stimulates adipocyte browning via induction of apelin. Journal of Biological Chemistry 2020;295:14878–92. https://doi.org/10.1074/jbc.RA120.013834.
20. Khokher W, Iftikhar S, Beran A, Burmeister C, Kesireddy N, Altujjar M, et al. The Use Of Atenolol And Losartan In Reducing Aortic Dilation In Patients With Marfan Syndrome A Systematic Review And Meta-Analysis. JACC, 2022. 1808.
22. Kucukdurmaz F, Efe E, Kurutas EB, Olmez C, Temizer M, Resim S. Losartan treatment significantly attenuates the fibrotic changes in the corpus cavernosum of castrated rats. Rev Int Androl 2020;18:14–20. https://doi.org/10.1016/j.androl.2018.07.001.
26. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 2021;42:3599–726. https://doi.org/10.1093/eurheartj/ehab368.
27. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 2022;79:e263–421. https://doi.org/10.1016/j.jacc.2021.12.012.
28. BPOM. Cek BPOM. 2022. https://cekbpom.pom.go.id//home/produk/6gssti26g2f9uq59fpdvv8sdog/all/row/10/page/3/order/4/DESC/search/5/losartan
29. Tsiailanis AD, Renziehausen A, Kiriakidi S, Vrettos EI, Markopoulos GS, Sayyad N, et al. Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid. Free Radic Biol Med 2020;160:391–402. https://doi.org/10.1016/j.freeradbiomed.2020.08.007.
30. Joshi D, Katyal J, Arava S, Gupta YK. Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. Epilepsy and Behavior 2019;92:345–52. https://doi.org/10.1016/j.yebeh.2018.12.019.
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