Etiologi Arteriovenous Malformation (AVM)

Oleh :

dr.Nailla Fariq Alfiani

Etiologi arteriovenous malformation (AVM) atau malformasi arteriovenosa bersifat kongenital akibat gangguan proses diferensiasi dan maturasi pembuluh darah pada fase angiogenesis embrional, sehingga terbentuk shunt arteriovenosa tanpa kapiler intermediat.

Sebagian kecil kasus AVM bersifat didapat, terkait trauma, prosedur bedah, atau kondisi vaskulitis yang memicu neovaskularisasi abnormal. Faktor genetik tertentu, seperti mutasi pada ENG atau ACVRL1 pada hereditary hemorrhagic telangiectasia (HHT) syndrome, juga telah dilaporkan berperan.[3,7,10,11]

Defek Genetik

Referensi

3. Zyck S, Davidson CL, Sampath R. Arteriovenous Malformations of the Central Nervous System. StatPearls Publishing; 2025 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK531479/
4. Sen S. Arteriovenous Malformations. Medscape. Nov 2021. https://emedicine.medscape.com/article/1160167-overview#a5
7. Schimmel K, Ali MK, Tan SY, et al. Arteriovenous Malformations-Current Understanding of the Pathogenesis with Implications for Treatment. International journal of molecular sciences, 2021. 22(16), 9037. https://doi.org/10.3390/ijms22169037
10. Ota O. An Updated Review on the Pathogenesis of Brain Arteriovenous Malformations and Its Therapeutic Targets. Journal of Neuroendovascular Therapy. 2024. https://www.jstage.jst.go.jp/article/jnet/advpub/0/advpub_ra.2024-0008/_pdf
11. Slack JC, Warmke L. Arteriovenous Malformation. 2024. https://www.pathologyoutlines.com/topic/softtissuearteriovenousmalformation.html
12. Tanaka M. Basic Knowledge and Overview of Brain AVMs. Journal of neuroendovascular therapy, 2025. 19(1), 2024-0037. https://doi.org/10.5797/jnet.ra.2024-0037
13. Seebauer CT, Wiens B, Hintschich CA, et al. Targeting The Microenvironment in The Treatment of Arteriovenous Malformations. Angiogenesis, 2024. 27, 91–103. https://doi.org/10.1007/s10456-023-09896-3
14. Swatan JP, Islamiyah WR, Sani AF, et al. Initial Clinical Presentations and Morphological Characteristics of Cerebral AVM in A Tertiary Health Center – Does Gender Matter?, World Neurosurgery, 2025. Volume 27, 100475, ISSN 2590-1397. 2025. https://doi.org/10.1016/j.wnsx.2025.100475.
15. UPMC. Arteriovenous Malformation (AVM). 2024. https://www.upmc.com/services/heart-vascular/conditions/arteriovenous-malformation
43. Pollock BE, Flickinger JC, Lunsford LD, Bissonette DJ, Kondziolka D. Factors that predict the bleeding risk of cerebral arteriovenous malformations. Stroke. 1996 Jan;27(1):1-6. doi: 10.1161/01.str.27.1.1.
44. Koester SW, Batista S, Bertani R, Yengo-Kahn A, Roth S, Chitale R, Dewan M. Angiographic factors leading to hemorrhage in AVMs: A systematic review and meta-analysis. Neurosurg Rev. 2023 Mar 20;46(1):72. doi: 10.1007/s10143-023-01971-z.

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Masuk atau Daftar

Nomor Ponsel Sudah Terdaftar

Masuk dengan Email

Masuk dengan Email

Masuk dengan Facebook

Etiologi Arteriovenous Malformation (AVM)

Referensi

Masuk atau Daftar

Artikel Terkait