Etiologi Juvenile Angiofibroma

Oleh :

dr.Nailla Fariq Alfiani

Etiologi juvenile angiofibroma belum dipahami secara jelas, tetapi melibatkan faktor genetik, hormonal, dan embriologis. Interaksi antara faktor-faktor ini bisa menghasilkan pertumbuhan lokal agresif dan hipervaskularisasi, yang merupakan ciri khas juvenile angiofibroma yang mendasari risiko perdarahan.[1-4,14,15]

Teori Embriologis dan Vaskular

Menurut teori embriologis dan vaskular, juvenile angiofibroma berasal dari sisa struktur vaskular atau neural crest selama perkembangan nasofaring, termasuk pleksus arteri lengkung pertama dan cabang pertama (first branchial arch). Sisa ini bisa terdiferensiasi abnormal menjadi jaringan fibrovaskular, yang menjelaskan lokasi tumor yang khas di sekitar foramen sphenopalatine.[14,16]

Referensi

1. Nakayama S, Nishio J, Aoki M, Koga K, Nabeshima K, Yamamoto T. Angiofibroma of soft tissue: Current status of pathology and genetics. Histol Histopathol. 2022 Aug;37(8):717-722. doi: 10.14670/HH-18-444.
2. Josef Shargorodsky. Juvenile angiofibroma. UF Health. 2023. https://ufhealth.org/conditions-and-treatments/juvenile-angiofibroma
3. Shah UK. Juvenile angiofibroma. MSD Manual. 2025. https://www.msdmanuals.com/professional/pediatrics/miscellaneous-ear-nose-and-throat-disorders-in-children/juvenile-angiofibromas
4. Newman M, Nguyen TBV, McHugh T, Reddy K, Sommer DD. Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review. J Otolaryngol Head Neck Surg. 2023 Dec 19;52(1):85. doi: 10.1186/s40463-023-00687-w.
5. Alla SSM, Alla D, Ratheesh V, Ramineni PK, Singh A, K V, Siddiqua A. Juvenile Nasopharyngeal Angiofibroma: A Case Report of a Rare Adolescent Head and Neck Tumor. Cureus. 2023 Jan 11;15(1):e33633. doi: 10.7759/cureus.33633.
6. Arulappan LAS. Extranasopharyngeal angiofibroma in an adolescent male: a case report. International Journal of Otorhinolaryngology and Head and Neck Surgery. 2019;5(5):1416–1418. https://doi.org/10.18203/issn.2454-5929.ijohns20193895
7. Safhi FA, Al-Hazani TMI, Jalal AS, et al. FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management. J Appl Genet. 2023 Dec;64(4):749-758. doi: 10.1007/s13353-023-00780-w.
8. Fang R, Sun W, Shi J, Xu R, Peng L, Lai Y, Chen F, Wen Y, Wen W, Li J. Risk Factors and Characteristics of the Recurrence of Juvenile Nasopharyngeal Angiofibroma: A 22-Year Experience With 123 Cases at a Tertiary Center. Clin Exp Otorhinolaryngol. 2022 Nov;15(4):364-371. doi: 10.21053/ceo.2022.01053.
9. Attya HMA, Hassouna MS, Shawky AA, Abdelmalek ME. Recurrent angiofibroma: analysis of risk factors and common sites of recurrence. Eur Arch Otorhinolaryngol. 2025 Jul;282(7):3611-3618. doi: 10.1007/s00405-025-09476-9.
14. Bernhard Schick, Lukas Pillong, and Silke Wemmert. The Embryological Basis of Juvenile Angiofibroma: A Unifying Hypothesis for Tumor Pathogenesis. J Clinical Research and Reports. 2025;19(5). doi:10.31579/2690-1919/521.
15. Doody J, Adil EA, Trenor CC, Cunningham MJ. The Genetic and Molecular Determinants of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review. Annals of Otology, Rhinology & Laryngology. 2019;128(11):1061-1072. doi:10.1177/0003489419850194. https://journals.sagepub.com/doi/abs/10.1177/0003489419850194
16. Pieter NAL, et al. Juvenile nasopharyngeal angiofibroma characteristics at Dr. Wahidin Sudirohusodo Hospital Makassar 2011–2021. In Proceedings of the 19th Otorhinolaryngology Head and Neck Surgery National Congress (PERHATIKL 2022), Advances in Health Sciences Research. 2022. https://doi.org/10.2991/978-94-6463-280-4_37

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Etiologi Juvenile Angiofibroma

Referensi

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